For more than 25 years, we have been recognized as a leader in chromatography solutions. We design, manufacture, use and sell optimized preparative chromatography systems based on innovative and proven technologies for your biopharmaceutical purification applications. Our biochromatography solutions are available from lab to process scale.
We offer single units and complete systems including:
Our process expertise enables us to reduce upstream and downstream development times using advanced methodologies including, where applicable, proprietary computer modeling tools.
The biopharmaceutical industry cannot compromise when it comes to quality and patient safety. Our solutions comply with all regulatory and quality requirements. They ensure the highest quality and safety levels while optimizing purity and yield and also adhering to the FDA PAT (Process Analytical Technologies) guidelines.
We offer a complete range of biochromatography solutions including columns, packing & unpacking stations and chromatography systems to match the requirements of your biochromatography step.
All our equipment has sanitary design and is fully compatible with GMP operations (includes FAT/SAT and a full documentation package). Our equipment complies with EC directives (DESP guidance) and conforms to ASME
code of construction.
|Packing & Unpacking
|LP150.500.VE 5||150||8||PU S||Pilot||1 - 50|
|LP200.500.VE 5||200||12||PU S||S||1 - 150|
|LP300.500.VE 5||300||32||PU S||S||1 - 150|
|LP450.500.VE 5||450||70||PU S/M||M||20 - 500|
|LP600.500.VE 5||600||125||PU M||M||20 - 500|
|LP800.350.VE 5||800||150||PU M/L||L||50 - 1200|
|LP1000.350.VE 5||1000||230||PU L||L||50 - 1200|
|LP1200.350.VE 5||1200||330||PU L||XL||200 - 3000|
|LP1400.350.VE 5||1400||450||PU L||XL||200 - 3000|
Prochrom®-Bio columns are the result of Novasep’s experience in developing, supplying and operating cGMP processes using preparative and process-scale high performance and low pressure liquid chromatography columns. Prochrom®-Bio columns’ unique design includes a hydraulically actuated piston and specially designed packing/unpacking valves to provide consistent and optimum performance. The time required to pack and unpack Prochrom®-Bio columns is drastically reduced when using Novasep’s automated packing & unpacking station. This unique packing & unpacking station along with its specific procedure enable the fastest operation and the most reproducible results. Prochrom®-Bio columns’ performance is maximized when used in conjunction with our Prochrom® Hipersep-Bio chromatography systems.
The same technology at all sizes
We offer 3 models of packing and unpacking stations adapted to the column size. These stations provide:
|Phenyl SepharoseTM FF 90 μm||LP1000||12||12||2900|
|Q SepharoseTM FF||LP1000||12||12||2500|
|Q SepharoseTM FF||LP600||30||22||3100|
|SP SepharoseTM FF||LP150||15||15||2500|
|DEAE 650 M||LP150||15||15||4120|
|Heparine SepharoseTM CL6B||LP1400||12||22||2100|
Our fully automated Prochrom® Hipersep-Bio LPLC systems are designed for process development, pilot-scale and production-scale downstream processing. Scalability is ensured using the same design from lab to large
Prochrom® Hipersep-Bio systems suit any biochromatography columns and offer maximum performance with Prochrom®-Bio columns for bed volumes from 1 to 450 L and column diameters from 150 mm to 1,400 mm I.D.
Their proven design will meet your specific process needs:
|Prochrom® Hipersep-Bio Systems|
|Flow Rate Range (LPH)||1 - 50||1- 150||20 - 500||50 - 1200||200 - 3000|
|Pressure Rating (bar)||5|
|Pressure Rating (bar)||High performance, PAT-compliant in-line dilution|
|Fraction Collection||5 to 10 valves, multiple automated fraction collection modes|
|Detection||Air, pressure, pH, conductivity, UV|
|Control System||Siemens WinAC platform - iFix SCADA|
Hipersep® SE-Bio control software provides automated and safe operations of the solvent module under cGMP conditions:
Hipersep® SE-Bio software provides user-friendly, secure, traceable chromatography processes. Main functions include: