Tangential Flow Filtration Solutions:

TangenX® Sius Single-Use Products
TangenX® NovaSet Reusable Cassettes
TangenX® TFS Holders & Systems

Tangential Flow Filtration Offering for Biopharmaceutical Applications

We have developed a complete range of optimized Tangential Flow Filtration (TFF) cassettes & systems based on innovative and proven technologies for your biopharmaceutical purifications. We offer a broad range of TFF units, cassettes and systems with membrane areas from 0.01 m2 to 40 m2 and more… as well as a large range of cut-offs from 1 kD to 0.65 μm. We provide the solution adapted to your filtration strategy from lab to process scale:
  • TangenX® Hystream™ and Prostream™ modified PES (mPES) membranes for microfiltration and ultrafiltration applications for most biopharmaceutical processes. Our membranes offer the advantage of high flux with extremely low protein binding properties
  • TangenX® Sius™ single-use TFF cassettes
  • TangenX® Sius™ disposable FPI (Flow Path Inserts)
  • TangenX® NovaSet™ reusable TFF cassettes
  • TangenX® TFS: TFF holders and systems from lab to industrial scale

Our solutions for biopharmaceutical manufacturing provide you with:
Guaranteed Performance
With experience in most purification technologies, we can offer integrated process design and solutions, from lab to industrial scale. We guarantee the process transfer from pre-clinical to commercial scale and from disposable to reusable since Novasep’s entire range of filtration solutions are composed of the same materials and chemistry.
Shorter Time-to-Market
Our process expertise enables us to reduce upstream and downstream development times using advanced methodologies including, where applicable, proprietary computer modeling tools.
Regulatory Compliance
The biopharmaceutical industry cannot compromise when it comes to quality and patient safety. All our packets, cassettes and blocks are individually tested. Our solutions comply with all regulatory and quality requirements. They ensure the highest quality and safety levels while optimizing purity and yield. 

Range of Novasep TFF Solutions

We offer state-of-the-art, universal Tangential Flow Filtration (TFF) holders & systems for ultrafiltration and microfiltration from laboratory to industrial scale. They accommodate all commercial cassettes.

TangenX Products

Novasep Product Name

Key Features

Filtration Surface Area/Capacities

Packet

SiusTM-LS

Single-Use

0.01 m2 – 0.02 m2

NovaSetTM-LS

Reusable

Cassette

SiusTM-LS

Single-Use

0.1 m2

NovaSetTM-LS

Reusable

SiusTM

Single-Use

0.5 m2

NovaSetTM

Reusable

Block

SiusTM

Single-Use

1.5 m2 and 2.5 m2

NovaSetTM

Reusable

Flow Path Insert

SiusTM-LS LHV FPI

Single-Use

Up to 0.48 L/min

SiusTM-LS FPI

Single-Use

Up to 9 L/min

SiusTM 75 FPI

Single-Use

Up to 49 L/min

Holder

SiusTM-LS 2BMC

Stainless Steel

0.01 m2 – 0.5 m2

SiusTM-LS 4BMC

Stainless Steel

0.5 m2 – 5.0 m2

NovaSetTM-LS LHV

Low Hold Up Volume

0.01 m2 – 0.04 m2

NovaSetTM-LS Pilot

Multipurpose

0.1 m2 –0.5 m2

NovaSetTM-N50/N75

Stainless Steel

0.5 m2 – 7.5 m2

Lab System

NovaSetTM-LS LHV

Low Hold Up Volume

15 mL – 5 L sample

NovaSetTM-LS Pilot

Multipurpose

150 mL – 20 L sample

TangenX® Sius:

the first truly disposable TFF Cassette provides tangible benefits for your biomolecule purification

TFF page picture 1

Designed for Single-Use to Drastically Reduce Cost
SiusTM cassettes cost five times less than our average competitor’s reusable cassettes and offer an unmatched price/performance ratio (figure 1). With SiusTM presanitized and individually tested cassettes, we provide an economical breakthrough solution in TFF for the bioprocess industry.
Improved Performance
The SiusTM cassette incorporates a unique patented design allowing a consistent flux over time. Its superior performance versus competing products has been demonstrated by customers in controlled side-by-side comparisons with competitors’ membranes (table 1).

Improved Quality
The SiusTM cassette automated process assembly and individual cassette release-testing ensure exceptional
cassette-to-cassette reproducibility.

Cleaning Validation Made Easier
With no need to flush or measure water permeability rates, SiusTM cassettes reduce the amount of time and resources needed for testing and integration. With no need for membrane cleaning and measurement of water flux recovery, using SiusTM in single-use TFF operations will minimize cleaning and crosscontamination risks.

Shorter TFF Process Time
With reusable products, typically 50% of the total process time is devoted to processing the product, the remaining time is spent preparing and cleaning the TFF system. With SiusTM the process amounts to 80% of the total time, increasing process efficiency by 60%.

Cost-Effective Choice for Short Campaigns
SiusTM TFF technology is most beneficial at development and pilot scales (< 5 m2). Larger scales benefit when the number of process cycles is fewer than 20 (figure 2). Multi-purpose manufacturing suites are ideal candidates for single-use TFF.

Seamless Transfer to Reusable TFF for Long Term Production
All membranes and process contact materials of our NovasetTM reusable cassettes are also used in SiusTM, thereby ensuring full compatibility and consistent results when switching from a disposable to a reusable process strategy. We guarantee the process transfer to commercial scale.

TangenX® NovaSet Cassettes:

The most affordable reusable TFF cassettes using robust validated technology for your commercial biopharmaceutical production

TFF page picture 2

NovaSet™ TFF cassettes have been designed to provide you with optimal performance:

  • Reliable scale-up, from lab to manufacturing scale
  • Optimized channel geometry and enhanced device rigidity ensure hydraulic performance
  • Validated manufacturing process compliant with cGMP principles
  • QC lot release testing includes 100% device integrity and hydrodynamic testing
  • Individually packaged in a sealed foil lined bag and outer cardboard carton
  • Wet packed in 20% Glycerin and 0.1% Sodium Azide
  • Cut-offs from 1 kD to 0.65 μm
  • Membrane areas from 0.01 m2 to 2.5 m2
  • Stackable for a membrane area up to 40 m2 and greater…
  • Adaptable with all existing holders

TangenX® TFS: TFF Systems & Holders 

TFF page picture 3
We offer state-of-the-art TFF holders & systems for ultrafiltration and microfiltration from laboratory to industrial scale. Our holders & systems can accommodate all your existing cassettes, including TangenX® reusable (NovaSet™) or disposable (Sius™) TFF cassettes.
All our equipment has sanitary design and is fully compatible with GMP operations. Our equipment also complies with EC directives (DESP guidance).

New!!!! SiusTM FPI: disposable flow path inserts and low cost SS holder

TFF page picture 4

The combination of SiusTM single-use cassettes with SiusTM FPI allows you to obtain a complete disposable filtration system, further reducing cleaning validation burden. Disposable flow path inserts are pre-sanitized and comply with USP Class VI. SiusTM FPI are available from laboratory to pilot scale. Each flow path insert is sold with a disposable polypropylene isolation plate in order to decrease the risk of contamination. Special low-cost SiusTM Stainless Steel holders have been designed to accommodate SiusTM FPI and cassettes, significantly reducing capital investment for new disposable TFF set-ups.